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Original Research
Shahram Parvaneh ORCID, Fatemeh Khademi, Gisya Abdi, Abdolhamid Alizadeh, Ali Mostafaie* ORCID
BioImpacts. 2021;11(4): 237-244. doi: 10.34172/bi.2021.34
PMCID: PMC8494260     PMID: 34631485     Scopus ID: 85113738808    
We could fabricate stable and high active Fe3O4@SiO2/NH2, and antibodies were conjugated to the surface of them from the Fc region, causing a higher binding capacity with no alteration or inhibition in the paratope area of the antibody molecule.
Schematic of the microfluidic device, top view and cross section of the middle part of the microfluidic device, tumor cell labeled with the functionalized antibodies with the Fe3O4 PMNPs, surface functionalization of the Si nanowires, SEM images of the middle part of the Si substrate with well-aligned SiNWs, SEM images of the tilted view of cancer cells trapped on the nanowires substrate microfluidic channel.


As a peer-reviewed international open-access journal, BioImpacts publishes articles on basic and translational aspects of pharmaceutical and biomedical sciences. 
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